Astaxanthin

Astaxanthin-based Phytocomplex

Key Features and Benefits of "our" astaxanthin

• Enhanced Astaxanthin Concentration: Our Astaxanthin-based Phytocomplex contains over 50% astaxanthin monoesters, significantly higher than traditional products. This high concentration ensures potent antioxidant activity, promoting better health outcomes even at lower doses.

• Reduced Saturated Fatty Acids: Through our selective separation process, we have minimized the presence of undesirable saturated fatty acids such as stearic and palmitic acid. This reduction enhances the overall health benefits of our product by minimizing exposure to unhealthy fats. 

• Proven Efficacy: Recent tests have demonstrated that our Astaxanthin-based Phytocomplex exhibits high antioxidant capacity in cellular models even at very low concentrations. This efficacy ensures that consumers can achieve optimal health benefits without needing to consume large quantities.

• Purity and Safety: AVEFLOR’s commitment to purity, potency, and safety means that our product is manufactured to the highest standards. Consumers can trust in the quality and efficacy of our Astaxanthin-based Phytocomplex.

Why is our astaxanthin unique?

Astaxanthin, known for its numerous health benefits, has long been marketed as oleoresin or biomass powder from the microalgae Hematococcus pluvialis. However, claims about the benefits attributed to astaxanthin overlook the complex composition and effects of other compounds found in the same products. The biomass of microalgae contains a modest concentration of astaxanthins, typically between 3-5% (w/w) [1]. Even with extraction techniques such as supercritical CO2 liquid extraction or extraction with organic solvents, the resulting oleoresins or extracts contain only 10-15% (w/w) astaxanthin, mainly mixed with a high content of acylglycerols and other minor carotenoids [2]. Unfortunately, this fact is often ignored, leaving consumers unaware that the acylglycerols contained in oleoresin are bound to stearic and palmitic acids, the consumption of which has been linked to obesity [3-5], inflammation [6-10] and diabetes [4,5].

In response to this gap in the market, AVEFLOR a.s. is at the forefront of innovation, closing the gap with our groundbreaking new astaxanthin monoesters-based product, called Astaxanthin-based Phytocomplex. Using state-of-the-art technology and a patented process to selectively separate astaxanthin monoesters from microalgae oleoresin, we have developed a highly effective antioxidant phytocomplex with a significantly higher concentration of astaxanthin monoesters (over 50%) while reducing the content of undesirable saturated fatty acids such as stearic and palmitic acid. This new product has recently been tested and has proven its high antioxidant capacity on cells even at a very low concentration [11]. This breakthrough marks a new chapter in the production and benefits of astaxanthin for medical and pharmaceutical applications.

Users can now reap the full benefits of astaxanthin at lower doses while minimizing exposure to unhealthy fatty acids. AVEFLOR's unwavering commitment to purity, potency and safety ensures that consumers can have confidence in the efficacy and safety of our product. Join us on this innovative journey and optimize your path to health and wellness with AVEFLOR a.s. For more information, please contact us using the form below.

References: 

[1] M.M.R. Shah, Y. Liang, J.J. Cheng, M. Daroch, Astaxanthin-producing green microalga Haematococcus pluvialis: from single cell to high value commercial products, Front. Plant Sci. 7 (2016) 531, https://doi.org/10.3389/fpls.2016.00531.

[2] Fábryová, T.; T°umová, L.; da Silva, D.C.; Pereira, D.M.; Andrade, P.B.; Valentão, P.; Hrouzek, P.; Kopecký, J.; Cheel, J. Isolation of astaxanthin monoesters from the microalgae Haematococcus pluvialis by high performance countercurrent chromatography (HPCCC) combined with high performance liquid chromatography (HPLC). Algal Res. 2020, 49, 101947. https://doi.org/10.1016/j.algal.2020.101947.

[3] Li, Y.; Wu, H.; Zhang, R.; Shu, G.; Wang, S.; Gao, P.; Zhu, X.; Jiang, Q.; Wang, L. Diet containing stearic acid increases food reward-related behaviors in mice compared with oleic acid. Brain Res Bull. 2020, 164, 45-54. https://doi.org/10.1016/j.brainresbull.2020.08.012.

[4] Espinosa, R.; Gutiérrez, K.; Rios, J.; Ormeño, F.; Yantén, L.; Galaz-Davison, P.; Ramírez-Sarmiento, C.A.; Parra, V.; Albornoz, A.; Alfaro, I.E.; et al. Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro. Cells 2022, 11, 920. https://doi.org/10.3390/cells11060920.

[5] Toledo, K.; Aranda, M.; Asenjo, S.; Sáez, K.; Bustos, P. Unsaturated fatty acids and insulin resistance in childhood obesity. J Pediatr Endocrinol Metab. 2014, 27, 503-510. https://doi.org/10.1515/jpem-2013-0281.

[6]  Anderson, E.K.; Hill, A.A.; Hasty, A.H. Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. Arterioscler Thromb Vasc Biol. 2012, 32, 1687-95. https://doi.org/10.1161/ATVBAHA.112.250142.

[7] Miao, H.; Chen, L.; Hao, L.; Zhang, X.; Chen, Y.; Ruan, Z.; Liang, H. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. Sci Rep. 2015, 5, 13092. https://doi-org.d360prx.biomed.cas.cz/10.1038/srep13092

[8] Zeng, J.; Zhang, Y.; Hao, J; Sun, Y.; Liu, S.; Bernlohr, D.A.; Sauter, E.R.; Cleary, M.P.; Suttles, J.; Li, B. Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein. J Immunol. 2018,15, 3407-3419. https://doi.org/10.4049/jimmunol.1701416. 

[9] Fróes, F.T.; Da Ré, C.; Taday, J.; Galland, F.; Gonçalves, C.A.; Leite, M.C. Palmitic acid, but not other long-chain saturated fatty acids, increases S100B protein and TNF-α secretion by astrocytes. Nutr Res. 2024, 122, 101-112. https://doi.org/10.1016/j.nutres.2023.12.007.

[10] Gupta, S.; Knight, A.G.; Gupta, S.; Keller, J.N.; Bruce-Keller, A.J. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J Neurochem. 2012,120, 1060-1071. https://doi.org/10.1111/j.1471-4159.2012.07660.x.

[11] Jurčacková, Z.; Ciglanová, D.; Mudroňová, D.; Tumová, L.; Bárcenas-Pérez, D.; Kopecký, J.; Koščová, J.; Cheel, J.; Hrčková, G. Astaxanthin Extract from Haematococcus pluvialis and Its Fractions of Astaxanthin Mono- and Diesters Obtained by CCC Show Differential Antioxidant and Cytoprotective Effects on Naïve-Mouse Spleen Cells. Antioxidants 2023, 12, 1144. https://doi.org/10.3390/antiox12061144. 

Naďa Huráňová - business development manager

+420 775 723 577 Call on working days from 8:00 am to 3:00 pm

bd@aveflor.cz

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